Although she was initially trained in graphic design and cinematography, the much-admired Panamanian artist Isabel De Obaldía is known for her drawings, paintings, sculptures, and videos. She has exhibited over four decades in numerous solo exhibitions and group shows in Panama, Europe, and the United States.

In 1989, a time of political turmoil in Panama, she created memorable works of protests against the dictatorship. In the 90s, she discovered the practice of glass sculpture, a medium in which she has achieved recognition for her extraordinary large-scale pieces, usually of male figures, wild animals, torsos, and heads. She has been exhibiting with the Mary-Anne Martin Fine Art Fine Art Gallery in New York since 1997, and recently, in 2022, she was invited to the 58th Carnegie International, the world's second-oldest biennial. In both her two-dimensional and glass works De Obaldía expresses a remarkable concern for the natural world, as well as for human beings and their often-difficult sociopolitical circumstances.